CHARGE TRANSFER COMPLEXES IN ITRACONAZOLE
Keywords:drug, human, infections, membranes, proteins, virus
Itraconazole (ITZ) is a distinguished antifungal representative that also has anticancer commotion. In this study, we recognize ITZ as a wide-ranging inhibitor of enteroviruses (e.g., poliovirus, coxsackievirus, enterovirus-71, rhinovirus). We exhibit that ITZ reduces viral RNA duplication by aiming oxy-sterol-binding protein (OSBP) and OSBP-related protein 4(ORP4). Time after time, OSW-1, a precise OSBP/ORP4 antagonist, too restrains enterovirus replication. Giveaway of OSBP inhibits virus replication, while over expression of OSBP or ORP4 offsets the antiviral belongings of ITZ and OSW-1. ITZ binds OSBP and inhibits its purpose, i.e., shuttling of cholesterol and phosphatidylinositol-4-phosphate between membranes, thus likely disturbing the virus-induced membrane alterations are also indispensable for viral replication organelle construction. ITZ also inhibits hepatitis C virus replication, which also relies on OSBP. Together, these data implicate OSBP/ORP4 as molecular targets of ITZ and point to an imperative utility of OSBP/ORP4-mediated lipid barter in virus replication that can be besieged by antiviral meds.
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Copyright (c) 2016 KUCHARLAPATI. DEEPTHI
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