Charge-Transfer Complexes of Rosuvastatin Calcium with ?-Acceptors

Authors

  • Kucharlapati Deepthi Research Scholar, Rayalaseema University, Kurnool, A.P., India
  • Dr. R. Narender Goud Professor, CMR Institute of Science and Technology, Hyhderabad, Telangana, IndiaECHNOLOGY HYDERABAD

DOI:

https://doi.org/10.24113/ijoscience.v3i3.61

Keywords:

atherosclerosis; cholesterol; rosuvastatin calcium; charge-transfer complexes; spectrophotometry; pharmaceutical analysis

Abstract

Studies were carried out to investigate the charge-transfer (CT) reaction of ROS-Ca, as a n-electron donor with various ?-acceptors: tetracyanoethylene, p-chloranilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, 2,3,5,6-tetrabromo-1,4-benzoquinone, 1,3,5-trinitrobenzene, 2,3,5,6-tetrachloro-1,4-benzoquinone, 7,7,8,8-tetracyano-quinodimethane, and 2,4,7-trinitro-9-fluorenone. Different colored CT complexes were obtained. The reaction mechanism and site of interaction were determined by ultraviolet-visible spectrophotometric techniques and computational molecular modeling. The formation of the colored complexes was utilized in the development of simple, rapid and accurate spectrophotometric methods for the determination of ROS-Ca. Under the optimum reaction conditions, linear relationships with good correlation coefficients (0.9984–0.9995) were found between the absorbances and the concentrations of ROS-Ca in the range of 2–200 ?g mL?1. The limits of detection ranged from 0.41 to 12.24 ?g mL?1. No interference could be observed from the additives commonly present in the tablets or from the drugs that are co-formulated with ROS-Ca in its combined formulations. The methods were successfully applied to the analysis of tablets with good accuracy and precision; the recovery percentages ranged from 99.54–100.46 ± 1.58–1.82%.

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Published

03/30/2017

How to Cite

Deepthi, K., & Goud, D. R. N. . (2017). Charge-Transfer Complexes of Rosuvastatin Calcium with ?-Acceptors. SMART MOVES JOURNAL IJOSCIENCE, 3(3), 6–11. https://doi.org/10.24113/ijoscience.v3i3.61