Ligational Behavior of Synthesized New Hydrazones Towards Oxovanadium (IV) Complexes and Their Antituberculosis Aspects


  • Dr. Alok Chandrayan Government Motilal Vigan Mahavidhayalaya, Bhopal, India
  • Dr. Alka Pradhan Government Motilal Vigan Mahavidhayalaya, Bhopal, India



The synthesis of some oxovanadium (IV) complexes with bidentate ligands (new synthesized biologically active hydrazones) derived from 2-methyl-4-(N-cyanoethyl)-N-benzenesulphonyl-benzylidene-3-oxo-[N-(substituted-1-phenyl)propanamido] hydrazone were analyzed. The complexes prepared were of the type [VO.L2] (where L= different new synthesized hydrazones).The characterization of these newly synthesized hydrazones and their metal complexes were done by IR, 1H-NMR spectral studies and elemental analysis. The infrared data of these complexes revealed the bidentate nature of the ligands and coordination to imino nitrogen of the amido group and azomethinic-nitrogen atoms. The new products were synthesized and evaluated for anti-tuberculosis activity against Mycobacterium tuberculosis H37RV in L.J.medium. The biological screening data indicates that the metal chelates are more potent than the parent ligands.


Download data is not yet available.


Pelosi, S. Pinelli, M. Sassi, J. Inoorganic Biochemistry, 98, 313.2004
K. Uehara, K. Morimoto, Y. Shijo, Analyst.,117, 977.1992
I. A. Tossadis, C. A. Bolos, P. n. Aslanidis, G. A. Katsoulos, Inorg. Chim. Acta, 133, 275. 1987.
J. A. Anten, D. Nicholis, J. M. Markpouos, O. Markopoulou, Polyhedron, 6, 1074. 1987
A. Maiti, S. Ghosh, Indian J. Chem., 28A, 980.1989
R. C. Aggarwal, N. K. Singh, R. P. Singh, Inorg. Chim. Acta, 29, 2794. 1981.
J. C. Craliz, J. C. Rub, D. Willis, J. Edger, Nature, 34, 176. 1955.
J. R. Dilworth, Coord. Chem. Rev., 21, 29. 1976.
J. R. Merchant, D. S. Clothia, J. Med. Chem.,13, 335. 1970
N. S. Biradar, B. R. Havinale, Inorg. Chim. Acta,17, 157. 1976
H. N. Fox, Science,116, 129. 1952.
P. A. S. Smith, The Chemistry of open-chain organic nitrogen compounds, New YorkVol. 2, 119. 1996
R.B. Singh, K. P. Jain, R. P. Singh, Talanta., 29, 77. 1982
M. E. U. Pozo, A. G. De Torres, J. M. C. Pavon, Analyst, 113, 547. 1988
A. Asuero, A. M. Jimenez, M. A. Herrador, Analyst, 111, 747. 1986
G. Nickless, J. Chromatogr., 313, 129. 1985
Z. Liu, F. C. Anson, Inorg. Chem.,40, 1333. 2001
D.Rehder, Coord. Chem. Rev.,182,297. 1999
K. H. Thomson, J. H. Mcneil, C. Orvig, Chem. Rev.,99, 2561. 1999
M. R. Maurya, S. Khurana, Shailendra, A. Azam, W. Zhang, D. Rehder, Eur. J. Inorg. Chem., 1966.2003
A. M. Evangelon, CR Oncol/Hemat,, 42, 249.2002
R. K. Agarwal, I. Chakraborti, Polish J. Chem., 68, 1491. 1994
The trans influence of the oxo ligand is reviewed by E. M. Shustrovitch, M. A. Porikoshits, Yu. A. Buslaev, Coord. Chem. Rev.,17,1. 1975
M. Sayaji Rao, K. Hussain Reddy, Indian J. Chem.,38A, 262. 1999
G. Paolucci, G. Marangoni, G. Barnoli, D. D. Clemente, J. Chem. Soc. Dalton Trans,1304. 1980
V. Pradhan, Oriental Jour. of Chem.,10, No. 1, 87-89. 1994
A. Pradhan, J. Indian Chem. Sic.,80, 143-144. 2003
Clinical Diagnosis and Management by laboratory methods, Todd, Sanford and Davidson, 17thedition, Edited by John Bernard Henry. 1998
Practical medical Microbiology Mackie and Mc Cartney, 13thedition,Edited by J. G. College, J. P. Dugoid.1989
Diagnostics Microbiology,Bailey and Scotts. .




How to Cite

Chandrayan, D. A., & Pradhan, D. A. (2019). Ligational Behavior of Synthesized New Hydrazones Towards Oxovanadium (IV) Complexes and Their Antituberculosis Aspects. SMART MOVES JOURNAL IJOSCIENCE, 5(12), 20–24.