Ligational Behavior of Synthesized New Hydrazones Towards Oxovanadium (IV) Complexes and Their Antituberculosis Aspects
The synthesis of some oxovanadium (IV) complexes with bidentate ligands (new synthesized biologically active hydrazones) derived from 2-methyl-4-(N-cyanoethyl)-N-benzenesulphonyl-benzylidene-3-oxo-[N-(substituted-1-phenyl)propanamido] hydrazone were analyzed. The complexes prepared were of the type [VO.L2] (where L= different new synthesized hydrazones).The characterization of these newly synthesized hydrazones and their metal complexes were done by IR, 1H-NMR spectral studies and elemental analysis. The infrared data of these complexes revealed the bidentate nature of the ligands and coordination to imino nitrogen of the amido group and azomethinic-nitrogen atoms. The new products were synthesized and evaluated for anti-tuberculosis activity against Mycobacterium tuberculosis H37RV in L.J.medium. The biological screening data indicates that the metal chelates are more potent than the parent ligands.
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